SOX6

Across TCGA pan-cancer cohorts, SOX6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SOX6 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SOX6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SOX6 expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and CCRCC are the cancer types where SOX6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Tertile	All	0.680	0.442	.008	4	view →
LSCC	OS	Quartile	All	1.000	0.765	.025	4	view →
CCRCC	OS	Quartile	III,IV	1.000	0.757	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SOX6–GBM (OS)

Open the GBM breakdown →