SOX6

Across TCGA pan-cancer cohorts, SOX6 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of SOX6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SOX6 RNA is repressed in tumor relative to normal tissue. In most cancer types SOX6 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, BRCA, and COAD are the cancer types where SOX6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−0.809	<.001	7	view →
BRCA	All	III,IV	−0.911	<.001	6	view →
COAD	Female	III,IV	−0.539	.001	6	view →
LUAD	Female	II,III,IV	−0.446	<.001	5	view →
THCA	All	All	−0.363	<.001	5	view →
KICH	All	All	−0.790	<.001	4	view →
BLCA	All	IV	−0.360	.034	4	view →
LIHC	All	All	−0.338	.009	3	view →
CHOL	All	All	+1.163	.014	2	view →
LUSC	All	All	+0.315	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

SOX6–KIRC

Open the KIRC breakdown →