SOX6

Across TCGA patient cohorts, SOX6 protein abundance is significantly associated with the RNA expression of many other genes, with 11,384 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SOX6-associated genes across cancer lineages are AKR1B1P3, RN7SL188P, and SERPINE1. Each is linked with SOX6 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOX6-to-partner and partner-to-SOX6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX6 versus AKR1B1P3 in LSCC, with a Pearson correlation of 0.81.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX6→partner) and Y-score (partner→SOX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1B1P3 →	+1.800	+1.251	<.001	<.001	3	4
LSCC	RN7SL188P →	+1.814	+1.254	<.001	<.001	3	4
CCRCC	SERPINE1 →	-1.596	-0.456	.002	.006	3	3
GBM	MAP3K8 →	-1.279	-0.759	<.001	<.001	3	3
LSCC	MPST →	+0.572	+0.932	<.001	<.001	3	3
GBM	MARCHF9 →	+1.315	+0.704	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,384 associations by consensus.

SOX6 vs AKR1B1P3 — LSCC

Explore this scatter interactively →