SOX6

Across TCGA patient cohorts, SOX6 mutation is significantly associated with the RNA expression of many other genes, with 5,219 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX6-associated genes across cancer lineages are POLE2, VRK1, and PSMD14. Each is linked with SOX6 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOX6-to-partner and partner-to-SOX6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POLE2 grouped by SOX6-low versus SOX6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX6→partner) and Y-score (partner→SOX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	POLE2 →	+0.537	+3.021	<.001	<.001	3	4
SKCM	VRK1 →	+0.574	+3.487	.003	.002	3	3
SKCM	PSMD14 →	+0.567	+2.913	.003	.001	3	3
SKCM	SLIRP →	+0.490	+2.925	<.001	.001	3	3
UCEC	PIMREG →	+0.888	+2.536	<.001	<.001	3	3
SKCM	TXNDC17 →	+0.504	+2.938	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,219 associations by consensus.

POLE2 by SOX6 expression — UCEC

Explore this box plot interactively →