SOX5

Across TCGA pan-cancer cohorts, SOX5 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SOX5 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SOX5 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SOX5 expression acts as an unfavorable survival marker.

LSCC and UCEC are the cancer types where SOX5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	II,III,IV	0.486	0.788	.021	4	view →
UCEC	OS	Median	All	0.847	0.962	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SOX5–LSCC (DFS)

Open the LSCC breakdown →