SOX5

Across TCGA patient cohorts, SOX5 protein abundance is significantly associated with the RNA expression of many other genes, with 11,760 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SOX5-associated genes across cancer lineages are MIR920, PES1, and GCAT. Each is linked with SOX5 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOX5-to-partner and partner-to-SOX5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX5 versus MIR920 in LSCC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX5→partner) and Y-score (partner→SOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MIR920 →	+1.081	+0.679	.006	.001	3	3
UCEC	PES1 →	+0.858	+0.355	.001	<.001	3	2
UCEC	GCAT →	+0.800	+0.317	.005	.001	3	2
UCEC	ANKRD54 →	+0.788	+0.541	<.001	<.001	3	2
UCEC	SNU13 →	+0.517	+0.331	.001	.003	3	2
UCEC	CBY1 →	+0.592	+0.469	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,760 associations by consensus.

SOX5 vs MIR920 — LSCC

Explore this scatter interactively →