SOX5

Across TCGA patient cohorts, SOX5 mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX5-associated genes across cancer lineages are MIG-6, Caspase-7-cleavedD198, and ATM. Each is linked with SOX5 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOX5-to-partner and partner-to-SOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by SOX5-low versus SOX5-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX5→partner) and Y-score (partner→SOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.090	+1.934	.029	.028	3	4
UCEC	Caspase-7-cleavedD198 →	+0.886	+1.945	<.001	.002	3	4
BLCA	ATM →	-0.812	-2.999	<.001	.035	3	3
BLCA	Bak →	+0.224	+3.000	.011	.036	2	4
COAD	Lck →	+0.425	+2.610	<.001	.005	3	3
UCEC	ERK2 →	+0.209	+1.874	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

MIG-6 by SOX5 expression — COAD

Explore this box plot interactively →