SOX5

Across TCGA cell cohorts, SOX5 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,421 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SOX5-associated GO terms across cancer lineages are Asymmetric neuroblast division, Nucleoside triphosphate biosynthetic process, and Proton motive force-driven ATP synthesis. Each is linked with SOX5 in more than 12 cancer types. Because this analysis shows association rather than direction, both SOX5-to-partner and partner-to-SOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Asymmetric neuroblast division grouped by SOX5-low versus SOX5-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX5→partner) and Y-score (partner→SOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Asymmetric neuroblast division →	-0.142	-1.688	<.001	<.001	3	13
SKIN	Nucleoside triphosphate biosynthetic process →	+0.082	+2.097	.002	<.001	3	10
SKIN	Proton motive force-driven ATP synthesis →	+0.060	+1.506	.005	.003	3	9
SKIN	ATP biosynthetic process →	+0.063	+1.532	.003	.002	3	8
SKIN	Ribonucleoside triphosphate biosynthetic process →	+0.071	+1.921	.006	.002	3	8
STOMACH	Regulation of nucleotide-excision repair →	+0.096	+1.178	.002	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,421 associations by consensus.

Asymmetric neuroblast division by SOX5 expression — LUNG_SCLC

Explore this box plot interactively →