SOX5

Across TCGA cell cohorts, SOX5 mutation is significantly associated with the RNA expression of many other genes, with 113 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX5-associated genes across cancer lineages are REG3A, IL36A, and CCDC70. Each is linked with SOX5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX5-to-partner and partner-to-SOX5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REG3A grouped by SOX5-low versus SOX5-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX5→partner) and Y-score (partner→SOX5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	REG3A →	+0.106	+5.786	<.001	<.001	3	2
LUNG_SCLC	IL36A →	+0.020	+4.643	<.001	.004	3	2
SOFT_TISSUE	CCDC70 →	+0.224	+4.459	<.001	.001	3	1
SOFT_TISSUE	CLEC4C →	+0.012	+4.392	<.001	.004	3	1
SOFT_TISSUE	TBC1D3K →	+0.353	+4.142	<.001	.003	3	1
SOFT_TISSUE	SPATA31A7 →	+0.147	+3.635	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 113 associations by consensus.

REG3A by SOX5 expression — BLOOD_Leukemia

Explore this box plot interactively →