SOX21

Across TCGA patient cohorts, SOX21 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX21-associated genes across cancer lineages are ATM, CD20, and eEF2. Each is linked with SOX21 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX21-to-partner and partner-to-SOX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SOX21-low versus SOX21-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX21→partner) and Y-score (partner→SOX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.523	-3.169	.035	.020	3	1
UCEC	CD20 →	+0.180	+3.189	.012	.010	3	1
UCEC	eEF2 →	+0.600	+3.169	.002	.020	2	1
UCEC	Notch1 →	+0.192	+2.817	.012	.036	2	1
UCEC	p62 Lck ligand →	+0.744	+3.009	<.001	.019	2	1
UCEC	PCNA →	+0.335	+3.169	.004	.020	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

ATM by SOX21 expression — UCEC

Explore this box plot interactively →