SOX21

Across TCGA pan-cancer cohorts, SOX21 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SOX21’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SOX21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOX21 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

LUAD, THCA, and BLCA are the cancer types where SOX21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+1.409	<.001	10	view →
THCA	All	III,IV	−0.225	<.001	9	view →
BLCA	Male	III,IV	+3.114	<.001	7	view →
LUSC	Female	All	+3.078	<.001	7	view →
KIRC	All	All	+0.053	<.001	7	view →
STAD	All	II,III,IV	−2.358	<.001	6	view →
PAAD	All	All	+2.485	.019	4	view →
KICH	All	All	+0.138	.009	4	view →
KIRP	All	II,III,IV	−0.018	.045	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SOX21–LUAD

Open the LUAD breakdown →