SOX21

Across TCGA cell cohorts, SOX21 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,726 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SOX21-associated GO terms across cancer lineages are Glial cell fate commitment, Endodermal cell fate specification, and B cell chemotaxis. Each is linked with SOX21 in more than 6 cancer types. Because this analysis shows association rather than direction, both SOX21-to-partner and partner-to-SOX21 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Glial cell fate commitment grouped by SOX21-low versus SOX21-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX21→partner) and Y-score (partner→SOX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Glial cell fate commitment →	+2.047	+2.468	<.001	.001	3	7
OESOPHAGUS	Endodermal cell fate specification →	+2.148	+2.627	<.001	<.001	3	6
URINARY_TRACT	B cell chemotaxis →	-1.084	-0.849	<.001	.006	3	6
STOMACH	Release of sequestered calcium ion into cytosol →	-0.095	-1.474	<.001	.001	3	5
UPPER_AERODIGESTIVE_TRACT	Calcium ion transport →	-0.065	-0.967	<.001	.001	3	5
LUNG_SCLC	Regulation of atrial cardiac muscle cell membrane depolarization →	-1.133	-1.788	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,726 associations by consensus.

Glial cell fate commitment by SOX21 expression — OESOPHAGUS

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