SOX21

Across TCGA cell cohorts, SOX21 protein abundance is significantly associated with the RNA expression of many other genes, with 2,678 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SOX21-associated genes across cancer lineages are DPYSL3, MEX3C, and ASPH. Each is linked with SOX21 in more than 6 cancer types. Because this analysis shows association rather than direction, both SOX21-to-partner and partner-to-SOX21 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SOX21 versus DPYSL3 in LUNG_SCLC, with a Pearson correlation of 0.77.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX21→partner) and Y-score (partner→SOX21) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DPYSL3 →	+3.244	+2.939	<.001	<.001	3	7
STOMACH	MEX3C →	+1.210	+2.307	.001	.002	3	5
BLOOD_Myeloma	ASPH →	+0.900	+1.970	.001	.002	3	5
PANCREAS	TSHZ1 →	+0.946	+2.081	.003	.007	3	5
URINARY_TRACT	CDR2 →	+0.970	+2.191	.009	.007	3	5
STOMACH	RGP1 →	+1.140	+2.729	.003	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,678 associations by consensus.

SOX21 vs DPYSL3 — LUNG_SCLC

Explore this scatter interactively →