Across TCGA cell cohorts, SOX18 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX18-associated genes across cancer lineages are IQCF5, C14orf180, and CPO. Each is linked with SOX18 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX18-to-partner and partner-to-SOX18 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX18→partner) and Y-score (partner→SOX18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.121	+5.201	<.001	.006	3	1
LARGE_INTESTINE	C14orf180 →	+0.117	+3.155	<.001	.008	3	1
LARGE_INTESTINE	CPO →	+0.156	+3.514	<.001	.007	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

SOX18 survival (RNA) · tumor vs normal (RNA) · all SOX18 data types