SOX17

Across TCGA patient cohorts, SOX17 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX17-associated genes across cancer lineages are FASN, CD20, and GATA3. Each is linked with SOX17 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX17-to-partner and partner-to-SOX17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by SOX17-low versus SOX17-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX17→partner) and Y-score (partner→SOX17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	FASN →	+0.557	+2.823	.006	.034	3	1
STAD	CD20 →	-0.176	-3.169	.024	.019	3	1
COAD	GATA3 →	+0.202	+3.178	.044	.010	3	1
COAD	Shc_pY317 →	-0.163	-3.161	.049	.019	3	1
UCEC	MSH6 →	-0.329	-3.906	.022	<.001	3	1
UCEC	PDK1 →	+0.163	+3.335	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FASN by SOX17 expression — STAD

Explore this box plot interactively →