SOX15

Across TCGA patient cohorts, SOX15 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX15-associated genes across cancer lineages are ATM, FOXO3a_pS318_S321, and Annexin-1. Each is linked with SOX15 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX15-to-partner and partner-to-SOX15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by SOX15-low versus SOX15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX15→partner) and Y-score (partner→SOX15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.522	-3.000	.046	.037	3	2
UCEC	FOXO3a_pS318_S321 →	-0.153	-3.000	.034	.037	3	1
UCEC	Annexin-1 →	+0.717	+2.827	.018	.035	3	1
UCEC	mTOR_pS2448 →	-0.214	-3.000	.013	.037	1	2
UCEC	JNK2 →	+0.255	+3.000	.026	.037	1	1
UCEC	C-Raf_pS338 →	-0.113	-3.000	.016	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

ATM by SOX15 expression — UCEC

Explore this box plot interactively →