SOX15

Across TCGA pan-cancer cohorts, SOX15 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated SOX15 data layer compared with 1 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SOX15 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SOX15 expression acts as an unfavorable survival marker, although some lineages such as UVM and UCS show a favorable association.

UVM, KIRC, and CHOL are the cancer types where SOX15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.750	0.366	<.001	101	view →
KIRC	DFS	Quartile	II,III,IV	0.390	0.680	<.001	94	view →
CHOL	OS	Quartile	All	0.267	0.829	<.001	59	view →
UCS	DFS	Median	III,IV	0.487	0.148	.005	50	view →
KICH	OS	Tertile	II,III,IV	0.700	1.000	.007	48	view →
ACC	DFS	Quartile	All	0.122	0.745	<.001	43	view →
OV	DFS	Median	IV	0.281	0.608	<.001	32	view →
SCLC	DFS	Quartile	All	0.602	0.251	.001	31	view →
SKCM	OS	Tertile	All	0.823	0.917	<.001	30	view →
HNSC	DFS	Median	IV	0.288	0.456	.002	28	view →
READ	DFS	Median	III,IV	0.433	0.754	.009	24	view →
SARC	DFS	Median	All	0.736	0.514	<.001	22	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

SOX15–UVM (OS)

Open the UVM breakdown →