SOX11

Across TCGA patient cohorts, SOX11 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOX11-associated genes across cancer lineages are mTOR_pS2448, PCNA, and ER-alpha. Each is linked with SOX11 in more than 2 cancer types. Because this analysis shows association rather than direction, both SOX11-to-partner and partner-to-SOX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by SOX11-low versus SOX11-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX11→partner) and Y-score (partner→SOX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	mTOR_pS2448 →	-0.133	-2.046	.004	<.001	3	3
UCEC	PCNA →	+0.161	+1.050	.006	.023	3	3
CESC	ER-alpha →	-0.665	-3.000	.036	.033	3	2
CESC	INPP4B →	-0.237	-3.000	.009	.033	3	2
READ	14-3-3_epsilon →	+0.181	+2.218	.005	.028	3	2
READ	RAD51 →	+0.148	+3.321	.023	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

mTOR_pS2448 by SOX11 expression — COAD

Explore this box plot interactively →