SOX11

Across TCGA pan-cancer cohorts, SOX11 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SOX11’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SOX11 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SOX11 is over-expressed in tumor, although a few such as READ show the opposite, repressed pattern.

KIRC, HNSC, and LIHC are the cancer types where SOX11 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOX11 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	+1.805	<.001	12	view →
HNSC	All	III,IV	+0.887	<.001	12	view →
LIHC	All	All	+0.102	<.001	8	view →
LUAD	Female	All	+1.367	<.001	7	view →
THCA	All	All	+0.505	<.001	7	view →
BRCA	Female	II,III,IV	+0.947	<.001	6	view →
LUSC	All	All	+0.864	<.001	5	view →
BLCA	Female	All	+0.246	<.001	5	view →
UCEC	All	III,IV	+0.221	.016	4	view →
CHOL	All	All	+0.371	.003	3	view →
STAD	Male	II,III,IV	+0.325	.013	2	view →
KIRP	Female	II,III,IV	+0.200	.049	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SOX11–KIRC

Open the KIRC breakdown →