SOX11

Across TCGA cell cohorts, SOX11 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,316 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SOX11-associated GO terms across cancer lineages are Positive regulation of double-strand break repair, Protein localization to cytoplasmic stress granule, and RNA splicing, via transesterification reactions with bulged adenosine as nucleophile. Each is linked with SOX11 in more than 9 cancer types. Because this analysis shows association rather than direction, both SOX11-to-partner and partner-to-SOX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of double-strand break repair grouped by SOX11-low versus SOX11-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX11→partner) and Y-score (partner→SOX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of double-strand break repair →	+0.066	+2.482	<.001	<.001	3	10
OVARY	Protein localization to cytoplasmic stress granule →	+0.114	+1.485	<.001	.002	3	8
LUNG_SCLC	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.057	+2.426	.009	.001	3	8
LUNG_SCLC	mRNA splicing, via spliceosome →	+0.057	+2.426	.009	.001	3	8
BONE	Regulation of double-strand break repair via homologous recombination →	+0.107	+3.478	<.001	<.001	3	8
BONE	Positive regulation of double-strand break repair via homologous recombination →	+0.093	+2.925	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,316 associations by consensus.

Positive regulation of double-strand break repair by SOX11 expression — BONE

Explore this box plot interactively →