SOX11

Across TCGA cell cohorts, SOX11 mutation is significantly associated with the RNA expression of many other genes, with 59 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOX11-associated genes across cancer lineages are MSGN1, MS4A14, and SPINK8. Each is linked with SOX11 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOX11-to-partner and partner-to-SOX11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSGN1 grouped by SOX11-low versus SOX11-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOX11→partner) and Y-score (partner→SOX11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.061	+3.023	<.001	.002	3	2
OESOPHAGUS	MS4A14 →	+0.053	+4.906	<.001	.006	3	1
OESOPHAGUS	SPINK8 →	+0.263	+4.906	<.001	.006	3	1
OESOPHAGUS	C2orf83 →	+0.020	+4.906	<.001	.006	3	1
OESOPHAGUS	MS4A12 →	+0.043	+4.906	<.001	.006	3	1
BLOOD_Leukemia	MMP27 →	+0.026	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 59 associations by consensus.

MSGN1 by SOX11 expression — LARGE_INTESTINE

Explore this box plot interactively →