SOS2

Across TCGA pan-cancer cohorts, SOS2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SOS2 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SOS2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SOS2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where SOS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Median	III,IV	0.867	0.544	.002	41	view →
PDAC	DFS	Median	III,IV	0.408	0.908	.004	12	view →
LUAD	OS	Quartile	III,IV	0.295	0.879	.010	8	view →
LSCC	DFS	Tertile	III,IV	0.896	0.514	.015	7	view →
GBM	DFS	Tertile	All	0.585	0.792	.023	5	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SOS2–CCRCC (OS)

Open the CCRCC breakdown →