SOS2

Across TCGA pan-cancer cohorts, SOS2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SOS2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where SOS2 RNA is repressed in tumor relative to normal tissue. In most cancer types SOS2 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KIRC are the cancer types where SOS2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SOS2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	−1.215	<.001	10	view →
THCA	All	II,III,IV	−0.651	<.001	9	view →
KIRC	All	III,IV	−0.480	<.001	9	view →
BRCA	Female	All	−0.352	<.001	6	view →
LIHC	All	All	+0.411	<.001	5	view →
HNSC	Female	All	+0.603	.003	4	view →
CHOL	Male	All	+1.341	<.001	3	view →
READ	All	All	−0.838	.001	3	view →
LUAD	Female	II,III,IV	−0.459	.002	3	view →
UCEC	All	All	−0.773	<.001	2	view →
LUSC	All	All	−0.283	.002	2	view →
PRAD	All	All	−0.200	.048	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SOS2–COAD

Open the COAD breakdown →