SOS2

Across TCGA patient cohorts, SOS2 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOS2-associated genes across cancer lineages are TFRC, FASN, and S6_pS240_S244. Each is linked with SOS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SOS2-to-partner and partner-to-SOS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by SOS2-low versus SOS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS2→partner) and Y-score (partner→SOS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TFRC →	+0.569	+2.115	<.001	<.001	3	4
UCEC	FASN →	+0.320	+1.584	.009	.034	3	3
UCEC	S6_pS240_S244 →	+0.261	+2.700	.041	.006	3	3
LUSC	p70-S6K →	+0.296	+3.179	.013	.010	3	2
LUSC	CD31 →	-0.172	-3.160	.041	.019	3	2
UCEC	FoxM1 →	+0.243	+2.115	.002	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

TFRC by SOS2 expression — UCEC

Explore this box plot interactively →