SOS2

Across TCGA cell cohorts, SOS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,079 significant associations in total. CNS shows the largest number of these associations.

The most reproducible SOS2-associated GO terms across cancer lineages are Golgi vesicle transport, Macroautophagy, and Process utilizing autophagic mechanism. Each is linked with SOS2 in more than 18 cancer types. Because this analysis shows association rather than direction, both SOS2-to-partner and partner-to-SOS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi vesicle transport grouped by SOS2-low versus SOS2-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS2→partner) and Y-score (partner→SOS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.074	+0.989	<.001	<.001	3	19
STOMACH	Macroautophagy →	+0.092	+1.280	<.001	<.001	3	18
STOMACH	Process utilizing autophagic mechanism →	+0.085	+1.233	<.001	<.001	3	17
LUNG_SCLC	Vesicle budding from membrane →	+0.072	+0.844	.001	<.001	3	17
OVARY	Vesicle targeting →	+0.071	+0.966	<.001	<.001	3	17
STOMACH	Autophagy →	+0.085	+1.233	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,079 associations by consensus.

Golgi vesicle transport by SOS2 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →