SOS2

Across TCGA cell cohorts, SOS2 mutation is significantly associated with the RNA expression of many other genes, with 1,063 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SOS2-associated genes across cancer lineages are OR2M3, C8orf74, and DPEP2NB. Each is linked with SOS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOS2-to-partner and partner-to-SOS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2M3 grouped by SOS2-low versus SOS2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOS2→partner) and Y-score (partner→SOS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR2M3 →	+0.020	+3.824	<.001	.001	3	2
SOFT_TISSUE	C8orf74 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	DPEP2NB →	+0.032	+4.930	<.001	.008	3	1
LUNG_SCLC	WFDC12 →	+0.153	+3.523	<.001	.008	3	1
LUNG_SCLC	HTR3D →	+0.016	+4.058	<.001	.007	3	1
LUNG_SCLC	PRAMEF10 →	+0.708	+4.058	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,063 associations by consensus.

OR2M3 by SOS2 expression — BLOOD_Leukemia

Explore this box plot interactively →