SORL1

Across TCGA pan-cancer cohorts, SORL1 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of SORL1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SORL1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SORL1 is over-expressed in tumor, although a few such as HNSC show the opposite, repressed pattern.

LUAD, CCRCC, and HNSC are the cancer types where SORL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SORL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+0.530	<.001	8	view →
CCRCC	Male	All	+0.268	<.001	6	view →
HNSC	Male	III,IV	−0.194	.015	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

SORL1–LUAD

Open the LUAD breakdown →