SORL1

Across TCGA patient cohorts, SORL1 protein abundance is significantly associated with the RNA expression of many other genes, with 16,168 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SORL1-associated genes across cancer lineages are YEATS2, SNAI2, and TMEM158. Each is linked with SORL1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SORL1-to-partner and partner-to-SORL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SORL1 versus YEATS2 in OV, with a Pearson correlation of -0.31.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORL1→partner) and Y-score (partner→SORL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	YEATS2 →	-0.525	-0.383	.004	<.001	3	5
GBM	SNAI2 →	-1.213	-0.440	<.001	.002	3	5
BRCA	TMEM158 →	-1.031	-0.424	.001	.002	3	5
OV	MSANTD3 →	-0.728	-0.670	<.001	<.001	3	5
OV	RGS4 →	-1.052	-0.514	<.001	<.001	3	4
OV	GLT8D2 →	-1.082	-0.462	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,168 associations by consensus.

SORL1 vs YEATS2 — OV

Explore this scatter interactively →