SORL1

Across TCGA patient cohorts, SORL1 mutation is significantly associated with the total protein of many other genes, with 82 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORL1-associated genes across cancer lineages are Caspase-7-cleavedD198, Src, and eEF2. Each is linked with SORL1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SORL1-to-partner and partner-to-SORL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SORL1-low versus SORL1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORL1→partner) and Y-score (partner→SORL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.261	+2.230	<.001	.006	3	6
STAD	Src →	-0.270	-3.000	.043	.034	3	4
LUAD	eEF2 →	+0.337	+3.169	<.001	.019	3	4
UCEC	ERK2 →	+0.163	+2.807	<.001	<.001	3	4
UCEC	PCNA →	+0.120	+1.280	.030	.049	3	4
UCEC	ASNS →	+0.327	+1.321	<.001	.010	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 82 associations by consensus.

Caspase-7-cleavedD198 by SORL1 expression — COAD

Explore this box plot interactively →