SORL1

Across TCGA cell cohorts, SORL1 RNA expression is significantly associated with the RNA expression of many other genes, with 11,104 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SORL1-associated genes across cancer lineages are SLC37A1, SPINT1, and CDC42BPG. Each is linked with SORL1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SORL1-to-partner and partner-to-SORL1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SORL1 versus SLC37A1 in URINARY_TRACT, with a Pearson correlation of 0.75.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORL1→partner) and Y-score (partner→SORL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	SLC37A1 →	+1.998	+2.795	<.001	<.001	3	11
BREAST	SPINT1 →	+3.947	+2.538	<.001	<.001	3	11
BREAST	CDC42BPG →	+2.523	+2.486	<.001	<.001	3	11
LIVER	SC5D →	+1.534	+2.354	<.001	<.001	3	11
URINARY_TRACT	CDH1 →	+5.077	+3.768	<.001	<.001	3	10
LUNG_NSCLC_LUSC	SYK →	+3.525	+2.093	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,104 associations by consensus.

SORL1 vs SLC37A1 — URINARY_TRACT

Explore this scatter interactively →