SORL1

Across TCGA cell cohorts, SORL1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,782 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SORL1-associated GO terms across cancer lineages are Regulation of neurofibrillary tangle assembly, Protein localization to cytoplasmic stress granule, and Negative regulation of mRNA catabolic process. Each is linked with SORL1 in more than 10 cancer types. Because this analysis shows association rather than direction, both SORL1-to-partner and partner-to-SORL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of neurofibrillary tangle assembly grouped by SORL1-low versus SORL1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SORL1→partner) and Y-score (partner→SORL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of neurofibrillary tangle assembly →	+0.200	+1.740	<.001	.002	3	11
OVARY	Protein localization to cytoplasmic stress granule →	+0.152	+1.974	<.001	<.001	3	11
URINARY_TRACT	Negative regulation of mRNA catabolic process →	+0.053	+1.814	.001	.006	3	10
LUNG_NSCLC_LUSC	Cytotoxic T cell degranulation →	+0.249	+2.632	.003	<.001	3	10
PANCREAS	Diet induced thermogenesis →	+0.531	+2.554	.006	<.001	3	10
OVARY	Regulation of amyloid-beta formation →	+0.121	+2.387	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,782 associations by consensus.

Regulation of neurofibrillary tangle assembly by SORL1 expression — LUNG_SCLC

Explore this box plot interactively →