SORCS3

Across TCGA pan-cancer cohorts, SORCS3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SORCS3 data layer compared with 22 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SORCS3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SORCS3 expression acts as an unfavorable survival marker, although some lineages such as STAD show a favorable association.

HNSC, COAD, and GBM are the cancer types where SORCS3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	II,III,IV	0.220	0.567	.004	12	view →
COAD	DFS	Median	IV	0.028	0.496	<.001	9	view →
GBM	OS	Median	All	0.030	0.416	<.001	6	view →
PRAD	DFS	Median	All	0.633	0.935	.001	6	view →
SCLC	DFS	Median	II,III,IV	0.151	0.575	.001	6	view →
ESCA	DFS	Median	III,IV	0.185	0.458	.020	6	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	6	view →
BLCA	DFS	Median	IV	0.107	0.480	.001	6	view →
LGG	OS	Median	All	0.407	0.799	.049	3	view →
READ	OS	Median	III,IV	0.287	0.747	.038	3	view →
STAD	DFS	Median	III,IV	0.856	0.315	.045	3	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

SORCS3–HNSC (DFS)

Open the HNSC breakdown →