SORCS3

Across TCGA pan-cancer cohorts, SORCS3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of SORCS3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where SORCS3 RNA is repressed in tumor relative to normal tissue. In most cancer types SORCS3 is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, KIRC, and COAD are the cancer types where SORCS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SORCS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−0.935	<.001	11	view →
KIRC	All	All	+1.490	<.001	8	view →
COAD	All	II,III,IV	−0.182	<.001	8	view →
STAD	All	All	−0.476	<.001	7	view →
UCEC	All	All	−0.695	<.001	6	view →
KIRP	All	IV	−0.612	<.001	5	view →
READ	All	All	−0.355	.020	4	view →
BRCA	Female	All	+0.178	.002	4	view →
LUAD	Female	II,III,IV	+0.132	.004	4	view →
PRAD	All	All	−0.067	<.001	2	view →
BLCA	All	IV	−0.058	.005	2	view →
THCA	Female	III,IV	−0.046	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

SORCS3–KICH

Open the KICH breakdown →