SORCS3

Across TCGA patient cohorts, SORCS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 7,329 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible SORCS3-associated proteins across cancer lineages are DTX3L_S539, DPYSL3, and MSRB3. Each is linked with SORCS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SORCS3-to-partner and partner-to-SORCS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SORCS3 versus DTX3L_S539 in LSCC, with a Pearson correlation of -0.38.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS3→partner) and Y-score (partner→SORCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DTX3L_S539 →	-0.446	-0.442	<.001	<.001	3	5
BRCA	DPYSL3 →	+0.689	+0.173	<.001	<.001	2	5
BRCA	MSRB3 →	+0.806	+0.176	<.001	.002	3	4
BRCA	ISLR →	+0.814	+0.156	<.001	<.001	3	4
PDAC	TLN2 →	+0.494	+0.412	<.001	<.001	3	4
HNSC	SPAST_S268 →	+0.681	+0.417	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,329 associations by consensus.

SORCS3 vs DTX3L_S539 — LSCC

Explore this scatter interactively →