SORCS3

Across TCGA patient cohorts, SORCS3 mutation is significantly associated with the total protein of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORCS3-associated genes across cancer lineages are Cyclin-E2, 4E-BP1, and Cyclin-B1. Each is linked with SORCS3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SORCS3-to-partner and partner-to-SORCS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by SORCS3-low versus SORCS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS3→partner) and Y-score (partner→SORCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-E2 →	+0.188	+2.000	<.001	<.001	3	5
UCEC	4E-BP1 →	+0.398	+2.237	<.001	<.001	3	4
UCEC	Cyclin-B1 →	+0.748	+1.784	<.001	<.001	3	4
LUAD	INPP4B →	-0.288	-2.459	.034	.017	3	3
LUAD	4E-BP1_pT37_T46 →	+0.336	+1.584	.005	.032	3	3
UCEC	eIF4G →	+0.223	+2.087	.011	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Cyclin-E2 by SORCS3 expression — UCEC

Explore this box plot interactively →