SORCS3

Across TCGA cell cohorts, SORCS3 mutation is significantly associated with the RNA expression of many other genes, with 1,154 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SORCS3-associated genes across cancer lineages are OR13H1, KCNJ5, and BRAF. Each is linked with SORCS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SORCS3-to-partner and partner-to-SORCS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13H1 grouped by SORCS3-low versus SORCS3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORCS3→partner) and Y-score (partner→SORCS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR13H1 →	+0.090	+3.475	<.001	.006	3	2
LUNG_NSCLC_LUAD	KCNJ5 →	+0.076	+3.273	.004	.009	3	2
LUNG_NSCLC_LUAD	BRAF →	+0.435	+2.736	.008	.001	3	2
LARGE_INTESTINE	SDAD1 →	+0.467	+3.131	.002	.008	3	2
LARGE_INTESTINE	NOA1 →	+0.548	+2.502	.001	.005	3	2
LUNG_SCLC	ZNF705A →	+0.034	+3.626	.009	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,154 associations by consensus.

OR13H1 by SORCS3 expression — BLOOD_Leukemia

Explore this box plot interactively →