SORBS3

Across TCGA pan-cancer cohorts, SORBS3 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SORBS3 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher SORBS3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SORBS3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where SORBS3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.649	0.322	.008	14	view →
PDAC	OS	Median	II,III,IV	0.933	0.741	.010	11	view →
LUAD	DFS	Median	All	0.846	0.620	<.001	9	view →
LSCC	OS	Median	II,III,IV	0.877	1.000	.012	7	view →
GBM	DFS	Tertile	All	0.297	0.464	.023	6	view →
HNSC	DFS	Tertile	II,III,IV	0.894	0.986	.036	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SORBS3–CCRCC (DFS)

Open the CCRCC breakdown →