SORBS3

Across TCGA pan-cancer cohorts, SORBS3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SORBS3’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where SORBS3 RNA is repressed in tumor relative to normal tissue. In most cancer types SORBS3 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

LUAD, KICH, and BLCA are the cancer types where SORBS3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SORBS3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	−1.281	<.001	9	view →
KICH	Female	All	−2.088	<.001	8	view →
BLCA	All	IV	−1.599	.002	8	view →
KIRC	Female	All	+0.656	<.001	8	view →
COAD	Female	II,III,IV	−0.539	<.001	8	view →
THCA	Male	III,IV	−0.715	<.001	7	view →
UCEC	All	All	−1.196	<.001	6	view →
LUSC	Male	All	−0.854	<.001	6	view →
BRCA	All	II,III,IV	−0.632	<.001	6	view →
HNSC	Male	III,IV	+0.559	.018	5	view →
READ	All	All	−0.741	<.001	3	view →
PRAD	All	All	−0.274	.031	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SORBS3–LUAD

Open the LUAD breakdown →