SORBS3

Across TCGA patient cohorts, SORBS3 mutation is significantly associated with the RNA expression of many other genes, with 1,846 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORBS3-associated genes across cancer lineages are RNA5SP415, OC90, and OR8K4P. Each is linked with SORBS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SORBS3-to-partner and partner-to-SORBS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP415 grouped by SORBS3-low versus SORBS3-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS3→partner) and Y-score (partner→SORBS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RNA5SP415 →	+1.457	+6.733	<.001	<.001	3	3
BRCA	OC90 →	+0.264	+5.760	<.001	.003	3	2
LUAD	OR8K4P →	+0.059	+7.930	<.001	.008	3	2
BLCA	MIR1263 →	+0.596	+6.632	<.001	<.001	3	2
BLCA	IPPKP1 →	+0.057	+5.289	<.001	.003	3	2
BLCA	S100A11P7 →	+1.333	+5.064	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,846 associations by consensus.

RNA5SP415 by SORBS3 expression — LUSC

Explore this box plot interactively →