SORBS3

Across TCGA cell cohorts, SORBS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,572 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible SORBS3-associated GO terms across cancer lineages are Actin filament depolymerization, Protein depolymerization, and Positive regulation of stress fiber assembly. Each is linked with SORBS3 in more than 12 cancer types. Because this analysis shows association rather than direction, both SORBS3-to-partner and partner-to-SORBS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by SORBS3-low versus SORBS3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS3→partner) and Y-score (partner→SORBS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Actin filament depolymerization →	+0.240	+1.315	<.001	.001	3	13
URINARY_TRACT	Protein depolymerization →	+0.154	+2.092	<.001	.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of stress fiber assembly →	+0.169	+1.321	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of actin filament bundle assembly →	+0.177	+1.336	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Regulation of stress fiber assembly →	+0.079	+1.052	.001	.006	2	12
BREAST	Positive regulation of cell-substrate adhesion →	+0.142	+2.598	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,572 associations by consensus.

Actin filament depolymerization by SORBS3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →