SORBS3

Across TCGA cell cohorts, SORBS3 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SORBS3-associated genes across cancer lineages are MAGEB4, CCDC70, and TEX101. Each is linked with SORBS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SORBS3-to-partner and partner-to-SORBS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by SORBS3-low versus SORBS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS3→partner) and Y-score (partner→SORBS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.012	+3.678	<.001	.001	3	1
LARGE_INTESTINE	CCDC70 →	+0.027	+2.921	.007	.005	3	1
LARGE_INTESTINE	TEX101 →	+0.171	+3.708	<.001	.004	3	1
LARGE_INTESTINE	FAM153B →	+0.521	+3.841	<.001	.001	3	1
LARGE_INTESTINE	TAFA1 →	+0.209	+2.688	.003	.008	3	1
LARGE_INTESTINE	MINAR2 →	+0.027	+2.882	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MAGEB4 by SORBS3 expression — LARGE_INTESTINE

Explore this box plot interactively →