SORBS2

Across TCGA pan-cancer cohorts, SORBS2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SORBS2 data layer compared with 21 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SORBS2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SORBS2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and CCRCC are the cancer types where SORBS2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	All	0.911	0.672	<.001	59	view →
UCEC	DFS	Tertile	All	0.952	0.671	.001	18	view →
CCRCC	DFS	Tertile	III,IV	0.763	0.290	.002	14	view →
LUAD	DFS	Quartile	III,IV	0.198	0.802	.007	11	view →
LSCC	DFS	Tertile	II,III,IV	0.834	1.000	.022	7	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SORBS2–PDAC (DFS)

Open the PDAC breakdown →