SORBS2

Across TCGA patient cohorts, SORBS2 mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SORBS2-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and c-Kit. Each is linked with SORBS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SORBS2-to-partner and partner-to-SORBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SORBS2-low versus SORBS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS2→partner) and Y-score (partner→SORBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.538	+1.452	<.001	.002	3	4
UCEC	eIF4E →	+0.187	+1.621	<.001	<.001	3	3
COAD	c-Kit →	-0.541	-1.874	.018	.049	3	3
STAD	Cyclin-E2 →	+0.194	+2.190	.002	.033	3	3
SKCM	GAPDH →	+0.489	+3.169	.037	.017	3	3
STAD	Caveolin-1 →	-0.797	-3.000	.024	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

Caspase-7-cleavedD198 by SORBS2 expression — UCEC

Explore this box plot interactively →