SORBS2

Across TCGA cell cohorts, SORBS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,258 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SORBS2-associated GO terms across cancer lineages are Positive regulation of matrix metallopeptidase secretion, Positive regulation of T cell differentiation, and Positive regulation of T cell activation. Each is linked with SORBS2 in more than 8 cancer types. Because this analysis shows association rather than direction, both SORBS2-to-partner and partner-to-SORBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of matrix metallopeptidase secretion grouped by SORBS2-low versus SORBS2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS2→partner) and Y-score (partner→SORBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of matrix metallopeptidase secretion →	-0.205	-2.073	<.001	<.001	3	9
PANCREAS	Positive regulation of T cell differentiation →	+0.075	+1.813	<.001	.003	3	9
OVARY	Positive regulation of T cell activation →	+0.059	+1.830	<.001	.003	3	9
LUNG_SCLC	Physiological muscle hypertrophy →	+0.971	+2.335	<.001	<.001	3	8
LUNG_SCLC	Physiological cardiac muscle hypertrophy →	+0.971	+2.335	<.001	<.001	3	8
OVARY	Positive regulation of lymphocyte differentiation →	+0.076	+1.888	<.001	.002	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,258 associations by consensus.

Positive regulation of matrix metallopeptidase secretion by SORBS2 expression — BONE

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