SORBS2

Across TCGA cell cohorts, SORBS2 mutation is significantly associated with the RNA expression of many other genes, with 1,582 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SORBS2-associated genes across cancer lineages are SCGB3A2, PICK1, and MREG. Each is linked with SORBS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SORBS2-to-partner and partner-to-SORBS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB3A2 grouped by SORBS2-low versus SORBS2-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS2→partner) and Y-score (partner→SORBS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SCGB3A2 →	+0.642	+4.017	.003	.007	3	2
LARGE_INTESTINE	PICK1 →	+0.542	+3.459	.007	.001	3	2
LARGE_INTESTINE	MREG →	+0.522	+2.389	.001	.006	3	2
LARGE_INTESTINE	CNNM2 →	+0.507	+3.404	.007	<.001	3	2
LARGE_INTESTINE	PRSS53 →	+0.476	+2.000	<.001	.009	3	2
LARGE_INTESTINE	FAM151B →	+0.410	+2.459	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,582 associations by consensus.

SCGB3A2 by SORBS2 expression — OESOPHAGUS

Explore this box plot interactively →