SORBS1

Across TCGA cell cohorts, SORBS1 mutation is significantly associated with the RNA expression of many other genes, with 754 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SORBS1-associated genes across cancer lineages are A3GALT2, BMPR1A, and TMED5. Each is linked with SORBS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SORBS1-to-partner and partner-to-SORBS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, A3GALT2 grouped by SORBS1-low versus SORBS1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SORBS1→partner) and Y-score (partner→SORBS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	A3GALT2 →	+0.038	+4.191	<.001	.007	3	2
LARGE_INTESTINE	BMPR1A →	+0.589	+3.257	.005	.002	3	2
LARGE_INTESTINE	TMED5 →	+0.590	+3.169	<.001	.006	3	2
LARGE_INTESTINE	ZNF644 →	+0.418	+2.743	.001	.001	3	2
LARGE_INTESTINE	INPP5K →	+0.507	+3.064	.009	.009	3	2
LARGE_INTESTINE	PYURF →	+0.473	+2.389	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 754 associations by consensus.

A3GALT2 by SORBS1 expression — BLOOD_Lymphoma

Explore this box plot interactively →