SOD2

Across TCGA pan-cancer cohorts, SOD2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SOD2 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher SOD2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SOD2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

GBM, HNSC, and LUAD are the cancer types where SOD2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	OS	Median	All	0.407	0.670	.003	19	view →
HNSC	DFS	Median	IV	0.793	0.542	.014	13	view →
LUAD	DFS	Median	All	0.868	0.623	<.001	13	view →
CCRCC	DFS	Median	All	0.650	0.850	.028	2	view →
LSCC	DFS	Median	II,III,IV	0.567	0.821	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SOD2–GBM (OS)

Open the GBM breakdown →