SOD2

Across TCGA patient cohorts, SOD2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOD2-associated genes across cancer lineages are TIGAR, PDCD4, and Annexin-1. Each is linked with SOD2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOD2-to-partner and partner-to-SOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by SOD2-low versus SOD2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOD2→partner) and Y-score (partner→SOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.194	+3.026	.027	.019	3	1
UCEC	PDCD4 →	-0.930	-3.000	<.001	.037	1	1
UCEC	Annexin-1 →	+0.907	+3.000	.002	.037	1	1
UCEC	4E-BP1 →	+0.378	+3.000	.015	.037	1	1
UCEC	Cyclin-B1 →	+0.923	+3.000	.004	.037	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

TIGAR by SOD2 expression — UCEC

Explore this box plot interactively →