SOD2

Across TCGA cell cohorts, SOD2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,462 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SOD2-associated GO terms across cancer lineages are Regulation of membrane hyperpolarization, Response to isolation stress, and Hydrogen peroxide biosynthetic process. Each is linked with SOD2 in more than 17 cancer types. Because this analysis shows association rather than direction, both SOD2-to-partner and partner-to-SOD2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of membrane hyperpolarization grouped by SOD2-low versus SOD2-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SOD2→partner) and Y-score (partner→SOD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	Regulation of membrane hyperpolarization →	+0.387	+1.286	<.001	<.001	3	18
LUNG_SCLC	Response to isolation stress →	+0.182	+1.176	<.001	<.001	3	18
BREAST	Hydrogen peroxide biosynthetic process →	+0.236	+1.547	<.001	.002	3	18
URINARY_TRACT	Regulation of phenotypic switching →	+0.188	+1.877	.001	.001	3	17
BLOOD_Myeloma	Positive regulation of hydrogen peroxide biosynthetic process →	+0.294	+0.975	<.001	.001	2	17
KIDNEY	Response to silicon dioxide →	+0.256	+1.878	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,462 associations by consensus.

Regulation of membrane hyperpolarization by SOD2 expression — BLOOD_Myeloma

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