SOD1

Across TCGA patient cohorts, SOD1 mutation is significantly associated with the immune_cell of many other genes, with 3 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SOD1-associated genes across cancer lineages are GMP, Epithelial cells, and Mesangial cells. Each is linked with SOD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SOD1-to-partner and partner-to-SOD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GMP grouped by SOD1-low versus SOD1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SOD1→partner) and Y-score (partner→SOD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GMP →	+0.079	+3.849	<.001	.006	3	1
UCEC	Epithelial cells →	-0.084	-3.000	.043	.037	3	1
UCEC	Mesangial cells →	-0.050	-2.989	.024	.037	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

GMP by SOD1 expression — LUSC

Explore this box plot interactively →